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What is EPG?



What is EPG? What kind of application does EPG have? As a domestic technology company specializing in phospholipid high-end pharmaceutical excipients, AVT's products fully cover natural phospholipids, synthetic phospholipids, functionalized phospholipids and other subdivisions, and provide products such as oleic acid, sodium oleate, cholesterol, trehalose, sucrose, etc. Related accessories products. The editor will give you a detailed introduction to EPG phospholipids.

EPG CAS No. 383907-64-0,EPG Egg Yolk Phosphatidylglycerol-AVT (Shanghai) Pharmaceutical Tech Co., Ltd

EPG phospholipid, also known as egg yolk phosphatidyl glycerol, may be unfamiliar to many people, but as the two-year period of Alprostadil injection gains more and more attention in China, it has also become more and more complicated The injection researcher understood and began to use it in product development.

What is EPG?

Common name: Egg Yolk Phosphatidylglycerol

Product name: EPG

Chemical name: 1,2-Diacyl-sn-glycerol-3-phosphate-[1-rac-glycerol]

Molecular formula: C40H76NaO10P

Manufacturer:AVT (Shanghai) Pharmaceutical Tech Co., Ltd.

CAS No. 383907-64-0

DMF No. 8997

Record registration No. F20170000042

Grade: medicinal injection grade

Uses: liposome membrane material, emulsifier

Properties: This product is white to yellow powder

Purity: 95%~105% (see COA for details)

Solubility: soluble in chloroform, slightly soluble in ethanol, insoluble in water

Molecular weight: 782.284

Phase transition temperature: around -8℃, no definite value

Stability: easy to oxidize

EPG CAS No. 383907-64-0,EPG Egg Yolk Phosphatidylglycerol-AVT (Shanghai) Pharmaceutical Tech Co., Ltd

What is the source of EPG?

1. Extraction. The content of naturally occurring PG in egg yolk is very low, accounting for less than 1% of total phospholipids. Therefore, the difficulty and cost of obtaining natural phosphatidylglycerol by extraction are very high.

2. Chemical synthesis. The production of PG phospholipids in a fully synthetic manner has been widely used in industrial applications, and phospholipid products with a purity of not less than 99% can be obtained. Chemical synthesis is currently the main way to obtain EPG.

3. Biosynthesis. Although the biological stock of phosphatidylglycerol is small and difficult to extract, the biological deposit of phosphatidylcholine (PC) is very rich and can be obtained in large quantities, such as egg yolk lecithin and soybean lecithin. Using the catalysis of phospholipase D, PC can be converted into PG through head group exchange.

What are the applications of EPG?

In the field of pharmaceutical excipients, although PG is not as widely used as PC, due to its unique structure and physical and chemical properties, it has played an extremely important role as a key excipient in the development of some formulations. The most representative one is 2014 In January, Fuji Pharmaceutical launched Alprostadil injection with a 2-year shelf life. It is precisely because of the use of EPG to replace the oleic acid in the original prescription to improve the stability of the alprostadil fat emulsion, the successful realization of the shelf life of alprostadil injection from 1 year to 2 years, triggering industry changes!

In addition, EPG also has some applications in the development of liposome drugs, and research is still the main focus. Because of its low phase transition temperature, low rigidity, and negative charge, it is different from saturated PG phospholipids such as DPPG in application. It is often used to develop poorly soluble drugs or liposomes with special requirements.