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Common applications of HSPC hydrogenated soybean phosphatidylcholine

Time:2021-08-05

Views:905

HSPC hydrogenated soybean phosphatidylcholine as a commonly used semi-synthetic phosphatidylcholine, I believe you will not be unfamiliar, this article let AVT xiaobian to explain the specific application of HSPC hydrogenated soybean phosphatidylcholine!



1. Amphotericin B liposome Injection (Ambisome, 1990)
composition

成分

AmB

HSPC

DSPG

CHO

摩尔比

1

5

2

2.5

用量/支

50mg

213mg

84mg

52mg


Indications: severe depth ****.
HSPC usage: Dissolve in appropriate organic solvent with phospholipid and medicine, steam in water bath at 55℃, vacuum to make film.



2. Doxorubicin Liposome Injection (Doxil, 1995)

成分

AmB

HSPC

DSPG

CHO

摩尔比

17

56

39

5

用量/浓度

2mg/mL

9.58mg/mL

3.19mg/mL

3.19mg/mL

Indications: advanced ovarian *, multiple bone marrow *, and KAPosi's sarcoma with HIV.

HSPC usage: Dissolve in appropriate organic solvent with phospholipid, slowly and uniformly inject into water solution containing polyxorubicin under the condition of 55℃ water bath and rapid stirring to form uniform colostum.





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