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Synthetic phospholipid DSPC can be applied to various pharmaceutical preparations such as liposomes

Time:2021-11-15

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DSPC,distearoylphosphatidylcholine,a PC synthetic phospholipid widely used in many fields such as pharmaceutical preparations,in medicine, mainly used as pharmaceutical excipients, it can also be used in liposomes, microbubble ultrasound contrast agents and special lipid microspheres, drug complexes and other pharmaceutical preparations.

In 2015, the FDA approved Onivyde (Irinotecan liposome injection) for the treatment of patients with advanced pancreatic cancer. Onivyde is a topoisomerase 1 inhibitor encapsulated in lipid bilayer vesicles or liposomes. The content of DSPC is 6.81 mg/mL and the content of MPEG2000-DSPE is 0.12 mg/mL. Onivyde not only solves the problem of low solubility of irinotecan and cannot be administered by injection, but also improves the safety and effectiveness of irinotecan, which can effectively prolong the life cycle of patients with advanced pancreatic cancer without affecting their quality of life.

The DSPC phase transition temperature is 55°C, so it is often used to prepare liposomes. The liposome DaunoXome (daunorubicin liposome) developed by Diatos Company contains 65% DSPC in the membrane component. After the liposome is made of Nexstar, the accumulation of the drug in the solid tumor site increases, which improves the curative effect. At the same time, it reduces the toxicity to the heart. It is approved for the treatment of AIDS/AIDS-related Kaposi's sarcoma and has been marketed in more than 20 countries.

As a common synthetic phospholipid, DSPC can also be widely used in special drug-carrying systems such as contrast agents, drug complexes, and lipid microspheres.


Synthetic phospholipid DSPC can be applied to various pharmaceutical preparations such as liposomes-AVT (Shanghai) Pharmaceutical Tech Co., Ltd


Speaking of Distearoylphosphatidylcholine DSPC, AVT provides you with two grades of DSPC phospholipids, reagent grade and pharmaceutical injection grade. The specific product information is introduced as follows:

1. Distearoylphosphatidylcholine DSPC reagent grade pharmaceutical excipients

Product name: Distearoylphosphatidylcholine

Chemical name: 1,2-Distearoyl-sn-glycerol-3-phosphocholine

Common name: DSPC

CAS Number: 816-94-4

Grade: reagent grade

Molecular weight: 790.17

Molecular formula: C44H88NO8P

Product characteristics: white powder.

Storage conditions: 2-8℃, shading and airtight

2. Distearoylphosphatidylcholine DSPC pharmaceutical injection grade pharmaceutical excipients

Product name: Distearoylphosphatidylcholine (for injection)

Chemical name: 1,2-Distearoyl-sn-glycerol-3-phosphocholine

Common name: DSPC

CAS Number: 816-94-4

Registration Number: F20180000837

DMF number: 6252

Grade: medicinal injection grade

Molecular weight: 790.17

Molecular formula: C44H88NO8P

Applicable fields: liposome membrane material, emulsifier

Product characteristics: white powder, hygroscopic. Easily soluble in chloroform, slightly soluble in methanol and ethanol, slightly soluble in acetone

Storage conditions: below -20℃, shading and airtight

If you are interested in Synthetic phospholipid DSPC, you can call us at 400-6262 623!

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